Chemistry of PNA Peptide Nucleic Acid Essay -- Biology Polymer Medical

AbstractFor this report I chose to study PNA, or peptide nucleic acid, a biological polymerthat was related to the biomedical field of research. I was very interested in thissynthesized molecule because of its inimitable and remarkable properties, comparativelyto other nucleic acids such as the more than commonly known DNA, or deoxyribonucleicacid, and RNA, or ribonucleic acid. I also wanted to understand its uses and possible usesin everyday life. My main goal was to learn astir(predicate) the social system, significance, and clinicalapplications of PNA.EssayImagine being able to solve problems such as cancer by just a few molecules.Think of each of the lives that would be saved by this miracle molecule. Well, there may besuch a thing, and that too a polymer that is similar to DNA. This wonder-molecule iscalled peptide nucleic acid, or PNA. PNAs can bind with senior high specificity to a selectedtarget in a gene sequence, so this makes them very significant, especially in the m edicinaland biotechnological perspectives. However, before learning how PNA is useful in thatway, it is of the essence(p) to learn about its properties and their meaning. Peptide nucleic acid is avery special polymer that is unique in its characteristics, functions, and use in the modernworld.3Although PNA may not be a common household word,it is quite familiar to molecular scientists all over the world. Itis a potent structural mimic of DNA with a pseudopeptidebackbone. This is clear shown by the image on the left, as thecentral composition of both nucleic acids arerelatively analogous. The phosphodiesterbackbone of DNA is replaced in PNA by a 2-aminoethyl-glycine linkage. The structure ofthe molecule itself is a glycine molecule with... ...nant Melanoma. 27 Oct. 2006. 29July 2008 .5 Mondhe, Madhav. Figure 2. Chemical Structure of PNA & DNA. PNA binding toDNA. Digital image. Madhav Mondhe. 24 Oct. 2007. 29 July 2008.Pellestor, Franck. PRINS and PNA Technologies in chromosomal Inv estigation. NewYork Nova Science, Incorporated, 2006.4 Vocke, Eric, Everardo Macias, and Virginia Evans. PNA Triplex Ball and Stick.Digital image. DNA Triplexes. 29 July 2008gcntrl.htmllocation.3 Vocke, Eric, Everardo Macias, and Virginia Evans. PNA Triplex Black and White.Digital image. DNA Triplexes. 29 July 2008gcntrl.htmllocation.